Our Publications

X Wei, J Li, Z Cheng, S We, G Yu, ML Olsen, Decoding the Epigenetic Landscape: Insights into 5mC and 5hmC patterns and impacts on gene regulation in mouse cortical cell-types, bioRxiv, 2024.07. 06.602342, Link

CM Cleary, JL. Browning, M Armbruster, CR Sobrinho, MLStrain, S Jahanbani, J Soto-Perez, VE Hawkins, CG Dulla, ML Olsen, DK Mulkey, Kir4.1 channels are required for astrocyte CO2/H+-sensitivity and the drive to breathe.Communications Biology, 2024, PMID 38548965, Link

X Wei, JL Browning, ML Olsen. Neuron and astrocyte specific 5mC and 5hmC signatures of BDNF’s receptor, TrkB, Frontiers in Molecular Neuroscience, (2024) Link

JL Browning, K Wilson, X Wei, O Shandra, D Mahmutovic, S Robel, P VandeVord, ML Olsen. Applying Proteomics and Computational Approach to Identify Novel Targets in Blast Associated Post-Traumatic Epilepsy, International Journal of Molecular Sciences, 2024, PMID 38474127  Link

DC Patel, N Swift, B Tewari, JL Browning, C Prim, L Chaunsali, I Kimbrough, ML Olsen, H Sontheimer. Increased expression of chondroitin sulfate proteoglycans in the dentate gyrus and amygdala causes postinfectious seizures, Brain, 2023, PMID: 38146224, Link

SA Liddelow*, ML Olsen*, MV Sofronview.* Reactive Astrocytes. Cold Spring Harbor Laboratory Perspectives in Biology, 2024 *corresponding authors, Link

J Leonard, X Wei, JL Browning, EK Gudenschwager-Basso, J Li, Elizabeth A Harris, ML Olsen, Michelle H Theus, Transcriptomic alterations in cortical astrocytes following the development of post-traumatic epilepsy, (2024) Scientific Reports, PMID 38600221 Link

LE Fritsch, C Kelly, J Leanard, X Wei, S Brindley, EA Harris, AM Kaloss, N DeFoor, S Paul, H O’Malley, J Ju, ML Olsen, MH Theus, AM Pickrell, STING-dependent signaling in microglia or peripheral immune cells orchestrates the early inflammatory response and influences brain injury outcome Journal of Neuroscience, 2024, PMID 38360749,  Link

B Bacskaick, M Bambrick, JL Browning, M Butler, R Carroll, BA Costine-Bartell, J Davis, R Di Sapia, AC Duhaime, JR Geraghty, EK Gudenschwager Basso, JJ Gugger, M Johnson, V Johnson,  P Klein, K Lillis, JA Loeb, B Maharathi, D Mahmutovic, L Martinez-Ramirez, Y Mikhaeil-Demo, F Moro, K Normoyle, Olsen ML, DC Patel, R Raiyyani, T Ravizza,  M Rizzi, S Robel, A Serafini, O Shandra, H Sontheimer, K Staley, W Stewart, DM Talos, F Testai, MH Theus, A Ulyanova, P VandeVord, A Vezzani,  T Volanth, AK Wagner,  KW Wang, J Wolf, J Wong, E Zanier. A team science approach for the preclinical and clinical characterization and biomarker development of post-traumatic epilepsy (PTE). Epilepsia Open, 2023, PMCID: PMC10472380 Link

EK Gudenschwager-Basso, O Shandra, T Volanth, D Patel, C Kelly, JL Browning, X

Wei, D Mahmutovic, A M Kaloss, F Guilhaume Correa, J Decker, B Maharathi, S Robel, H Sontheimer, PJ VandeVord, ML Olsen*, MH Theus.* Atypical neurogenesis, astrogliosis and excessive hilar interneuron loss associates with the development of post traumatic epilepsy. Cells, 2023, PMID: 37174647, Link * corresponding authors

E Kowalski, E Soliman, C Kelly, J Ju, A Cash, A Hazy, C Jager, AM Kaloss1, EK  Gudenschwager Basso, H Ding, RD Hernandez, G Coleman, X Wang, ML Olsen, AM Pickrell, MH Theus. Monocyte pro-inflammatory phenotypic control by Ephrin type-A receptor4 mediates neural tissue damage, JCI Insight, 2022, PMID 35737458 Link

Torres-Ceja B, Olsen ML. A closer look at astrocyte morphology: Development, heterogeneity, and plasticity at astrocyte leaflets. Current Opinion in Neurobiology, May 2022, PMID 35544965 Link

MR Heaven, AW Herren, DL Flint, NL Pacheco, J Li, A Tang, F Khan, JE Goldman, BS Finney, ML Olsen. Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease with Severe Reactive Gliosis, Molecular and Cellular Proteomics, Jan 2022, PMID 34808356 Link

DK Mulkey, ML Olsen, M Ou, CM Cleary, G Du. Putative roles of astrocytes in general anesthesia. Current Neuropharmacology, 2022, PMID 33588730 Link

AF Gallucci, KC Patterson, AR Weit, WJ Van Der Pol, AK Percy, CD Morrow, SL Campbell and ML Olsen. Shared microbial community changes in female rats and humans with Rett syndrome, Progress in Neuropsychopharmacology & Biological Psychiatry, July 2021, PMID 33548354 Link

KC Patterson, U Kahanovitch, CM Gonçalves, JJ Hablitz, A Staruschenko, DK Mulkey, ML Olsen. Kir5.1-dependent CO2-sensitive currents contribute to astrocyte heterogeneity across brain regions, Glia, Feb 2021 PMID: 32865323 Link

M Ou, F Kuo, ML Olsen, G Du, DK Mulkey, Isoflurane inhibits a Kir4.1/5.1-like conductance in neonatal rat brainstem astrocytes and recombinant Kir4.1/5.1 channels in a heterologous expression system, Journal of Neurophysiology, Sept 2020 PMID: 32727273 Link

JL Boni, SE Nwaobi, CL Floyd and ML Olsen. DNA methylation: a mechanism for sustained alteration of Kir4.1 expression following central nervous system insult. Glia, July 2020 PMID: 32068308 Link

Uri Kahanovitch, ML Olsen. invited “Spotlight”, Glial SIK3: a central player in ion and volume homeostasis in Drosophila peripheral nerves, Journal of Cell Biology, Nov 2019, PMID 31723008 Link

LM Holt, NA Pacheco, RD Hernandez, NL Pacheco, BT Ceja, M Hussain and ML Olsen. Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1, eLIFE, Aug 2019, PMID 31433295 Link

U Kahanovitch, KC Patterson, R Hernandez and ML Olsen. Glial dysfunction in MeCP2 deficiency models: Implications for Rett syndrome, invited review, International Journal of Molecular Sciences, Aug 2019, PMID 31387202 Link

LM Holt, T Stoyanof and ML Olsen. Magnetic cell sorting for in vivo and in vitro astrocyte, neuron, and microglia analysis, Current Protocols in Neuroscience, June 2019, PMID 31216394 Link

M Brenner, A Messing and ML Olsen. AP-1 and the injury response of the GFAP promoter, Journal of Neuroscience Research, Feb 2019. PMID 30345544, Link

S James, V Hawkins, B Barna, D Ruskin, S Masino, T Moreira, ML Olsen, DK Mulkey. Adenosine signaling though A1 receptors inhibits chemosensitive neurons in the retrotrapezoid nucleus. eNEURO, Dec 2018 PMID 30627640 Link

U Kahanakovitch, VA Cuddapah, NL Pacheco, LM Holt, AK Percy, DK Mulkey and ML Olsen. MeCP2 deficiency leads to loss of glial Kir4.1, eNEURO, Feb 2018, PMID 29464197 Link

NL Pacheco, LM Holt, DA Crossman and ML Olsen. RNA sequencing and novel proteomics approaches reveal multi-cellular deficits in cortex of Rett syndrome mice, Molecular Autism, Oct 2017, PMID 29090078 Link

L Stewart, K Wang, A Khan, S Pati, D Pizarro, S Buckingham, ML Olsen, J Chatham, and L McMahon, Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus, Journal of Neuroscience, Aug 2017, PMID 28760863, Link

A Stoica, BR Larsen, M Assentoft, RH Jensen, LM Holt, F Vilhardt, B Vilsen, K Lykke-Hartman, ML Olsen and N MacAulay, The 2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered non-functional by the G301R familial hemiplegic migraine type 2-associated mutation, Glia, Nov 2017, PMID: 28787093 Link

KC Patterson, KM Arps, VE Hawkins, DK Mulkey and ML Olsen. Behavioral and Motor Phenotypes in a Novel Rat Model of Rett Syndrome, Human Molecular Genetics, Aug 2016, PMID:27329765 Link

SE Nwaobi, VA Cuddapah, KC Patterson, AC Randolph, and ML Olsen. The role of glial-specific Kir4.1 in normal and pathological states in the CNS. Acta Neuropathologica, March 2016 PMID: 26961251 Link

LM Holt and ML Olsen. Novel applications of magnetic cell sorting to analyze CNS cell-type specific gene and protein expression, PLos One Feb 2016, PMID 26919701 Link

ML Olsen*, BS Khakh, SN Skatchkov, M Zhou, CJ Rouach N. New insights into the critical role of astrocyte ion channels in homeostasis and neuron-glia signaling. Journal of Neuroscience Oct 2015, PMID 26468182 *Corresponding Author Link

VA Cuddapah, SE Nwaobi, AK Percy, and ML Olsen. MECP2’s role in regulating neural activity: pathophysiological perspectives, Degenerative Neurological and Neuromuscular Disease, Oct 2015, PMID 32669918 Link

HR Minkel, TZ Anwer, KM Arps, M Brenner, ML Olsen. Elevated GFAP induces astrocyte dysfunction in caudal brain regions: a potential mechanism for hindbrain involved symptoms in type II Alexander Disease, Glia, Dec 2015 PMID:26190408 Link

SE Nwaobi and ML Olsen. Correlating gene-specific DNA methylation changes with expression and transcriptional activity of astrocytic KCNJ10 (Kir4.1), Journal of Visualized Experiments, Sept 2015, PMID 26436772 Link

SL Campbell, JJ Hablitz and ML Olsen. Insufficient GLT-1 Glutamate Transport and Altered Astrocyte Biophysical Properties Contributes to Hyperexcitability in Cortical Dysplasia, Frontiers in Molecular Neuroscience Dec 2014, PMID:25565960 Link

X Tong, Y Ao, GC Faas, SE Nwaobi, J Xu, MD Haustein, MA Anderson, I Mody, ML Olsen, M.V. Sofroniew, B.S. Khakh. Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nature Neuroscience, March 2014 PMID:24686787 Link

This article was featured as editor’s choice VA Cuddapah, RB Pillai, KV Shekar, JB Lane, KJ Motil, SA Skinner, G McGwin, DC Tarquinio, DG Glaze, WE Kaufmann, A K Percy, JL Neul, ML Olsen. Methyl-CpG-binding protein 2 (MEPC2) mutation type is associated with disease severity in Rett Syndrome, Journal of Medical Genetics March 2014, PMID 24399845 Link

SE Nwaobi, SR Peramsetty, E Lin and ML Olsen. DNA methylation is a critical regulator of Kir4.1 in CNS development, Glia, March 2014, PMID:2441522 Link

R Raphemot, R Kadakia, ML Olsen, S Banerjee, E Days, SS Smith, CD Weaver and JS Denton. Development and validation of fluorescence- and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1. Assay and Drug Development Technologies, Nov 2013 PMID: 24266659 Link

ML Olsen, SL Campbell, CL Floyd, H Sontheimer, Spinal Cord Injury in vivo Causes Wide-Spread, Persistent Loss of Kir4.1 and GLT-1: Potential Benefits of Treatment with 17β-Estradiol, Brain, April 2010, PMID:20375134 Link

ML Olsen and H Sontheimer. Functional Implications for Kir4.1 Channels in Glial Biology: From K+ Buffering to Cell Differentiation, Journal of Neurochemistry, Aug 2008, PMID 18691387 Link

CM Habela, ML Olsen and H Sontheimer. ClC3 Is a Critical Regulator of Cell Cycle in Normal and Malignant Cells, Journal of Neuroscience, Sept 2008, PMID:18784301 Link

AK Weaver, ML Olsen, MB McFerrin and H Sontheimer. BK Channels are Coupled to IP3-receptors via Lipid Rafts: a Novel Mechanism for Coupling [Ca2+]i to Channel Activation, Journal of Biological Chemistry, Oct 2007, PMID:17711864 Link

ML Olsen, SL Campbell and H Sontheimer. Differential Distribution of Kir4.1 in Spinal Cord Astrocytes Suggests Regional Differences in K+ Homeostasis, Journal of Neurophysiology, Aug 2007, PMID 16369934 Link

ML Olsen, H Higashimori, SL Campbell, JJ Hablitz and H Sontheimer. Functional Expression of Kir4.1 Channels in Spinal Cord Astrocytes, Glia April 2006, PMID: 16369934, cover art, Link

ML Olsen, AK Weaver, P Ritch, H Sontheimer. Modulation of Glioma BK (gBK) Channels via erbB2, Journal of Neuroscience Research, July 2005, PMID: 15948146 Link

ML Olsen, H Sontheimer. Mislocalization of Kir Channels in Malignant Glia, Glia, April 2004 PMID 14999814, cover art, Link

ML Olsen, S Schade, SA Lyons, MD Amaral, H Sontheimer. Expression of Voltage-Gated Chloride Channels in Human Glioma Cells, Journal of Neuroscience, July 2003 PMID 12843258 Link